Explore Cutting-Edge Treatment Options with Cellmedi

As a company committed to advancing stem cell therapies for a variety of human diseases, we are driven by our mission to push the frontiers of regenerative medicine by making significant strides in research, development, and manufacturing. We have pioneered a new generation of stem cell-derived biological products and ground-breaking technologies for the application and preservation of mesenchymal stem cells and hematopoietic stem cells. These innovations have yielded exceptional results in early-stage clinical trials (Phase I/II) for treating neurodegenerative diseases. Moreover, our  transformative technologies extend beyond disease treatment into the broader fields including medical aesthetics.

At present, we offer the following applications of our stem cell-based therapies:

• Anti-ageing and rejuvenation: Enhancing collagen production to repair damaged skin cells, improving blood vessel elasticity, and maintaining muscle stability.
• Organ reconstruction: Leveraging the unique ability of self-renewal and cell type-specific differentiation of stems cells  for organ/tissue regeneration in the liver, kidneys, and bones, as applied  in clinical practice.
• Treatment of diseases: Addressing conditions in the digestive, nervous, immune, endocrine, and musculoskeletal systems.
• Sub health solutions: Improving sleep quality, strengthening immune function, boosting energy levels, and alleviating symptoms of chronic fatigue.

1.1 Umbilical Cord – Mesenchymal Stem Cells (UC-MSCs)

Specifications and effects:

1. Regeneration and repair:  UC-MSCs are pluripotent cells capable of differentiating into various cell types, including adipocytes (fat cells), osteocytes (bone cells), chondrocytes (cartilage cells), and myocytes (muscle cells). This makes them valuable source for tissue repair and regeneration in cases of injury and degenerative diseases.

2. Anti-inflammation: UC-MSCs possess powerful anti-inflammatory properties that promote tissue healing and reduce excessive inflammation, making them effective in treating chronic inflammatory diseases, such as rheumatoid arthritis.

3. Immune regulation: Due to their strong immune modulation capabilities, UC-MSCs can be utilized to treat immune-related conditions, including autoimmune disorders.

4. Vascular regeneration: UC-MSCs promote the formation of new blood vessels, which is essential for treating ischemic diseases and improving blood flow in damaged tissues.

5. Anti-fibrosis: UC-MSCs  exhibit anti-fibrotic effects, helping to prevent scar tissue and fibrosis, which is particularly beneficial in treating conditions like liver cirrhosis, pulmonary fibrosis, and other related conditions.

2.1 Multipotent Vascular Progenitor Cells (MVPCs)

Specifications and effects:

1. Repairing damaged blood vessels: Upon vessel injury, MVPCs migrate to the affected area and differentiate into the demanded types of vascular cells, contributing to vascular healing cells through multiple cellular mechanisms, including regeneration of extracellular matrix (ECM).

2. Enhancing tissue growth: MVPCs secrete a range of growth factors that induce the formation and maturation of new cells, which is critical for accelerating the recovery of damaged tissues.

3. Promoting angiogenesis: Antigenic factors generated by MVPCs stimulate the formation of new blood vessels, necessary for the regeneration and healing of tissues with a vascular component. 4. Differentiation capacity: MVPCs can differentiate into various cell types necessary for tissue repair and regeneration, including endothelial cells and smooth muscle cells.

3.1 Umbilical cord blood derived stem cell (UCB-SC)

Specifications and effects:

1. Multipotent differentiation ability: The strong multipotent differentiation capabilities of UCB-SC s allow them to develop into various cell types, including bone, fat, muscle, and nerve cells. This makes them highly effective in tissue repair and regeneration, particularly in treating injuries and degenerative conditions.

2. Anti-inflammation: With their potent immunomodulatory functions, UCB-SCs present as an alternative strategy for alleviating prolonged inflammation and restoring immune balance.

3. Enhanced proliferation and longevity: UCB-SCs have a higher proliferation rate and longer lifespan compared to adult stem cells, making them more suitable for long-term applications in regenerative medicine.

4. Low immunogenicity: UCB-SCs pose a lower risk of triggering an immune response than adult-derived cells, providing a safer option for clinical application, particularly in minimizing the risk of rejection.

5. Disease treatment: UCB-SCs can be used for treating conditions such as leukemia, autoimmune diseases, neurological disorders, and blood-related diseases.

4.1 Adipose derived stem cell (ADSC)

Specifications and effects:

1.Tissue regeneration and repair: The multitude of the advantages of ADSCs – including abundant availability, stable function and reduced immune rejection – making them ideal seed cells in tissue engineering for skin and bone, as well as in tissue repair for urinary tract and cardiovascular disease.

2. Anti-inflammation and immune regulation: ADSCs exert anti-inflammatory effects by secreting a large number of cytokines. Use of autologous ADSCs or cell-free ADSC approaches helps avoid the risk of immune rejection.

3. Aesthetic medicine and plastic surgery: ADSCs are widely used in fat grafting and lip filling procedures, such as breast augmentation and buttock bio molding, and facial contouring and rejuvenation.

4. Bone marrow-like stem cell (BMSC) regeneration: ADSCs share important characteristics with BMSCs and can undergo multi-lineage differentiation, making them a less invasive alternative for osteogenic regenerative applications such as bone tissue engineering. 

5. Multi-directional differentiation of ADSCs: Adipose tissue has been established as a rich source of stem cells capable of differentiating into a wide range of lineages, including osteogenic (bone), chondrogenic (cartilage), adipogenic (fat), cardio myogenic (heart muscle), hepatic (liver), and even neurogenic (neural cells) cells.

5.1 Personalized stem cell (PSC)

Specifications and effects:

1. Endocrine system regulation: The endocrine system controls body functions through the secretion of an array of hormones. The organogenesis and self-renewal of endocrine organs rely on tissue stem cells, which are also required for balancing and coordinating the endocrine and nervous systems to achieve homeostasis and respond appropriately to stress.

2. Nervous system repair: Stem cells can repair nerve cells, improve the transmission of nerve signals, and enhance neural communication within the body. This capability helps restore the natural neural activities, improving overall bodily control.

3. Organ protection: Many human organs undergo continuous cellular renewal throughout the ageing process or following tissue injury. Stem cells are indispensable in these physiological and reparative regenerations, owing to their ability to generate new cells to replace damaged or aging ones in organ tissue.

4. Metabolic function enhancement: A healthy metabolic state is maintained through the reciprocal fine-tuning between stem cell functions and cellular metabolism. The switch between metabolic pathways in response to ageing or diet is associated with stem cell transition from quiescence to proliferation. 

5. Urinary system function improvement: Stem cell-based regenerative medicine and tissue engineering have emerged as viable options for replacing diseased components of urinary tract, including kidney, bladder and urethra.

6.1 Fibroblast facial injection (FFI)

Specifications and effects:

1. Formation and repair of extracellular matrix (ECM): FFI are responsible for forming and repairing key components of the ECM, including collagen, elastin, glycoproteins, and proteoglycans. These components provide mechanical support and structure to tissues.

2. Wound healing: FFI play a crucial role in wound healing and tissue repair by enhancing the formation of new tissues and the production of ECM components, thus speeding up the healing process and tissue regeneration.

3. Skin regeneration: When injected into the dermis, FFI stimulate the formation of new collagen and elastin fibers, improving skin elasticity and firmness while reducing wrinkles.

4. Organ repair: FFI participate in the repair and regeneration of various organs, including the skin, liver, kidneys, and lungs.

5. Immune regulation: FFI play a role in modulating the immune response, enhancing the body’s defense mechanisms and aiding the treatment of autoimmune diseases and inflammatory conditions.

7.1 Osteoarthritis (OA) cell therapy

Specifications and effects:

1. Cartilage tissue regeneration: Cartilage stem cells can differentiate into cartilage cells and synthesize and secrete cartilage matrix, thereby contributing to cartilage regeneration and repair.

2. Joint injury repair: When implanted into damaged joint, cartilage stem cells can differentiate into cartilage cells, and fill the cartilage gap to restore joint function.

3. Anti-aging effects: Diminished chondrogenesis underscores age-related decline in bones and surrounding joint tissues, which is accompanied by excessive oxidative stress and local inflammatory mediators. This progressive deterioration can be mitigated by the replenishment of cartilage stem cells.

4. Wide source availability: Cartilage stem cells can be obtained from various tissues such as bone marrow, adipose tissue, synovium, and periosteum.

5. Treatment of osteoarthritis: Osteoarthritis is a degenerative disease, hallmarked by the loss of resident skeletal stem cell populations in the joints. Patients with osteoarthritis can benefit from the implantation of cartilage stem cells, as these cells promote cartilage repair and regeneration, slow joint degradation, and help restore joint function.

6. Cartilage injury repair: Apart from degenerative conditions, cartilage damage incurred by factors such as sports injuries can be treated with cartilage stem cell infusion, facilitating cartilage regeneration and rapid functional recovery.

We are proudly standing on the shoulders of giants who are spearheading cutting-edge immune cell technologies. We specialize in research and development of therapeutics utilizing DC cells, CIK cells, NK cells, CAR-T, TCRT, TLR, and tumor vaccines. Our research aims to overcome tumor immune escape and enhance the efficacy of tumor immunotherapy drugs. We collaborate with esteemed medical centers and institutions, including Peking University People’s Hospital, Tianjin Medical University Cancer Institute and Hospital, Zhengzhou University First Affiliated Hospital. This fruitful partnership leads to the development of alpha-MSC stem cell tumor immunotherapy technology and cell differentiation technologies.

8 Umbilical cord blood Nature Killer (UCB-NK)
9 Autologous NK cell

Specifications and effects:

1. Natural cytotoxicity: NK cells can identify and attack harmful, infected or cancerous cells, primarily through the release of perforin and TNF, targeting cells that display abnormal or foreign markers.

2. Antiviral and antitumor activity: By selectively destroying infected or transformed cells through recognition of stress-induced ligands, NK cells inhibit tumor growth and viral infections. They also influence the function of other immune cells and the overall immune responses by producing inflammatory cytokines and chemokines..

3. Rapid response: Serving as the first line of host defense against pathogens and tumor growth, NK cells respond rapidly, typically within hours of encountering target cells.

10 Cytokine-induced killer (CIK)

Specifications and effects:

1. Targeted killing: The MHC-unrestricted cytotoxicity of immune effectors CIK cells, composed of heterogenous subpopulations, endows them with a broad spectrum of anti-viral and anti-tumor activity, effective against both hematological and solid malignancies. CIK cells can infiltrate the tumor microenvironment, directly targeting and eliminating tumor cells. 

2. Cytokine production: CIK cells produce high levels of cytokines, such as IFN-γ and TNF-α, quickly and efficiently, making them a powerful pharmacological tool for cancer immunotherapy.  

3. Fas/FasL-mediated killing: CIK cells can induce apoptosis in tumor cells through the Fas/FasL pathway, a critical mechanism underlying their potent tumor-specific toxicity. 4. Immune regulation: CIK cell therapy is used in allogeneic transplantation as a safe and effective immunosuppressant to suppress graft-versus-host disease (GVHD).

11 Tumor-infiltrating lymphocytes (TILs)

Specifications and effects:

The TIL method involves extracting infiltrating immune cells from the patient’s tumor and the surrounding tissue, then expanding them ex vivo with cytokines such as IL-2 and other costimulatory molecules. These expanded cells are subsequently reinfused into the patient’s body to target and eradicate cancer cells. TILs represent a collection of tumor-infiltrating T cells and NK cells, predominantly CD3⁺CD8⁺ T cells. By harnessing and strengthening the patient’s own immune force, TILs selectively target cancer-associated antigens, particularly patient-specific cancer neoantigens, with precision and robust response. TIL therapy is especially significant for treating tumours such as gastric cancer, colorectal cancer, melanoma, and others, with a focus on complex and recurring cases.

13 Personalized Tumor Vaccine

Specifications and effects

Immune cells are engaged in all three lines of host defense: physical/chemical barriers, non-specific innate responses, and specific adaptive responses, collectively protecting the body against external threats from the environment and internal challenges. Immune cells mainly perform the following functions:

1. Eliminate invaders and pathogens: Immune cells help remove foreign cells, pathogens, and metabolic waste from the body, playing a key role in maintaining immune balance.

2. Target and destroy tumor cells: By detecting and removing abnormal cells, they prevent tumor growth.

3. Regulate immune response: The complex networks of immune system are under dynamic multiscale regulations by immune cells and associated molecules, acting in concert to ensure a balanced defence reaction and preventing overactivation or underactivation of the immune system.

4. Cleansing: Immune cells such as neutrophils and macrophages are engaged in clearing cell debris and metabolic waste from the body, maintaining tissue homeostasis and minimizing inflammation.

5. Tumour recognition and response: In the context of tumour, both T cells and B cells can recognize tumour-specific antigens, forming complementary or synergistic interactions that yield anti-tumour toxicity. By producing antibodies, increasing antigen presentation to T cells, and secreting immune regulatory cytokines such as IL-10, B cells can impact T cell responses in cancer.

6. Natural killer (NK) cells: NK cells can kill both tumor cells and pathogens directly without prior sensitization.

1.Overview of the Function of Heat Shock Protein GP96

Messenger and Transport Molecule

Heat shock proteins are a class of molecular chaperones that facilitate the transport of materials and the transmission of information within cells. These ancient yet dynamic molecules have evolved throughout the history of life on Earth, developing a rich variety of types and functions. Their roles include defending against various external stresses, aiding in the folding of newly synthesized proteins, clearing protein waste, and transmitting antigen information to T cells.
As a molecular chaperone, heat shock protein GP96 binds to the antigenic peptide pool within cells and presents these bound antigens to MHC class I molecules through cross-presentation, thereby directly activating specific cytotoxic T cells. These cytotoxic T cells play a key role in killing tumor cells and in the treatment and control of tumors.

2.Technical Features (UC-MSCs)

-Safe and Effective
Biologically extracted from the placenta.
The U.S. FDA has designated autologous GP96 as an orphan drug for the treatment of various tumors.
-Reduces Recurrence Risk
After surgery, tumor patients using TK-129 immunotherapy can lower the risk of tumor recurrence and metastasis, with minimal adverse side effects and high cost-effectiveness.
-Novel Targets
Targets over 100 different oncofetal antigens.
Holds multiple national invention patents.
Specifically kills tumor cells and cancer stem cells.
-Accessible to All
Enhances immunity in healthy individuals, helping to fight tumors and viruses, while reducing healthcare burdens.
-Globally Exclusive
Globally unique technology for extracting heat shock proteins from the placenta.

3.GP96 Technology Research and Development Platform

4.Principle

4.1 Principle of heat shock protein GP96 in improving immunity

• Placenta preparation TP-129 is a heat shock protein GP96 extracted from healthy human placentas, combined with hundreds of carcinoembryonic antigens found in the placenta. Both the placenta and tumors are fast-growing, poorly differentiated tissues, and a variety of carcinoembryonic antigens derived from the placenta share similar antigenic properties with tumor antigens. Therefore, when healthy individuals immunized with placenta preparation, it can activate specific T cells in the body to kill rapidly growing tumor cells, thereby enhancing the body’s anti-tumor immunity.

4.2 Principle of heat shock protein GP96 in reducing the risk of tumor recurrence

• The placenta-derived heat shock protein GP96 forms complexes with hundreds of carcinoembryonic antigens and tumor stem cell antigens. It enters the cells by binding to CD91 molecules on the surface of antigen-presenting cells (mainly dendrite cells, or DCs). Once inside, GP96 presents the antigens it carries to downstream CD8+T cells and CD4+T cells via MHC class I and class II molecules, respectively. This process enables T cells to recognize the antigens and activate into tumor antigen-specific T cells, effectively killing the residual dormant tumor cells, micrometastasis, and tumor stem cells in post-operative patient, thus effectively reducing the risk of recurrence and metastasis.

4.3 The mechanism of TB-39 regulating immunity and improving symptoms

• High concentrations of GP96 can activate the NF-kB pathway through TLRs and upregulate the expression of FoxP3, thereby increasing the number of Tregs and enhancing their suppressive function, which helps restore the overactive immune system to return to homeostasis.

5.Product

TP-129-Enhancing anti-tumor immunity in healthy people

• Currently, many volunteers at high risk of developing cancer have received immune care with the placental preparation TP-129. The number of tumor-killing specific T cells has increased by 2 to 8 times, and the indicators of high tumor risk have shown improvement.

TK-129- Reducing the risk of cancer recurrence in patients

• The placenta preparation TK-129 can effectively kill dormant tumor cells, microlesions, and tumor stem
  cells remaining in the patient’ body after tumor surgery, effectively reducing the risk of recurrence and
  metastasis.

TB-39 injection – improving or eliminating autoimmune diseases

• Innovative: The first to develop recombinant heat shock protein GP96 to improve or eliminate the symptoms of autoimmune diseases.
• Safe and effective: Toxicology and pharmacodynamic studies demonstrated no significant toxicity to experimental animals at the administrated dosage.
• Broad-spectrum function: GP96 can interact with TLR2/4 receptors to activate regulatory T cells (Treg), making it a broad-spectrum drug that can improve or even eliminate the symptoms of autoimmune diseases.
• Novel target: GP96 is a newly discovered target for autoimmune diseases that we identified, providing a unique competitive advantage and has been pre-applied for China’s national Class I innovative drug status.
• Broad market: In China, systemic lupus erythematosus (SLE) affects over 100,000 patients, with an additional 100,000 new cases each year. The number of patients with other autoimmune diseases is even larger.

Cell storage, or cryostorage, is the process of preserving cells at ultra-low temperatures for future use. Currently, we offer high-quality preservation services for mesenchymal stem cells, mononuclear cells, immune cells, fibroblasts, and skin-derived cells sourced from human tissues. We employ advanced vitrification technology, an innovative method for successful cryopreservation of living cells without ice crystal formation, ensuring the viability of frozen cells exceeds 96% for long-term storage.

15.1 Placenta/umbilical cord mesenchymal stem cell storage

Main features:

Capitalizing on their potential of differentiation into over ten types of tissue cells and their immune regulatory functions, these cells are effective in treating a variety of systemic inflammatory diseases, particularly autoimmune disorders. They display traits of both embryonic and mesenchymal stem cells, while boasting additional advantages such as immune tolerance and circumvention of ethical dilemmas. These cells are often used as adjunctive therapy for immune regulation in patients with chronic conditions such as pulmonary fibrosis, cirrhosis, and diabetic foot.

Target clients: Everyone.Matching conditions: No matching required.

15.2 Amniotic membrane stem cell storage

Main features:

Amniotic stem cells are a mixture of somatic fetal stem and progenitor cells, possessing pluripotency similar to embryonic stem cells while retaining immunoregulatory effects akin to adult stem cell. As a rich source for tissue regeneration, amniotic fluid-derived stem cells can be banked for both allogeneic and autologous transplantation. They also have the potential for repeated use.

Target clients: Suitable for mothers and their families.

Matching conditions: No matching required.

Applications:

These cells can be used for neurological, hematological, digestive, immune, endocrine, and reproductive system diseases, liver and pulmonary injuries, as well as trauma repair (such as burns and skin damage), pregnancy-related tissue repair, postpartum recovery, anti-ageing treatment, and skin rejuvenation.

15.3 Placental hematopoietic stem cell storage

Main features:

These stem cells are the progenitors of blood cells, including red blood cells, white blood cells, platelets, but primarily immune cells. Placental hematopoietic stem cells have 5- to 10- fold greater likelihood of overcoming immune barriers compared to umbilical cord blood hematopoietic stem cells. They also demonstrate minimal immune rejection in children under 30 kg body weight during transplantation. The processing method is safe and noninvasive, using non-heparin processing technology, high-purity extraction, and D- nucleated cell sorting, which effectively avoids infection risk.

Matching conditions: Matching models are not necessary for all family members due to the  high compatibility of these stem cells.

15.4 Adult immune/fibroblast storage

Main features:

At 20 years old, the number and activity of immune cells reach their peak; at 40 years old, the activity and number of immune cells decline rapidly, only half of that at 20 years old; at 60 years old, the activity of immune cells is only 1/10 of that at 20 years old, and the quality of immune cells is declining every day!

16.1 clearance of blood lipids, uric acid, and stroke prevention

Blood purification therapy (apheresis) is a treatment that filters and removes disease-causing substances from the blood, such as low-density lipoprotein cholesterol, neutral fats, inflammatory substances, viruses, etc., using special filtration membranes. This process helps to eliminate inflammatory substances, excess sugars, and fats from the blood and cleans the blood vessel walls. It has significant therapeutic effects on conditions such as hypertension, hyperlipidemia, hyperglycemia, rheumatism, tumor-prone bodies, chronic inflammation, and allergic constitutions.

Free radicals, heavy metals, inflammatory substances, and homocysteine can corrode blood vessels and worsen inflammation, potentially leading to tumors. Through this blood purification process, these harmful substances are directly expelled from the body, helping to achieve a balance between the internal and external environments of the body.

Expected effects include: improving blood viscosity, preventing vascular blockage, enhancing vascular endothelial function, preventing cholesterol from entering the vessel walls, accelerating thrombus dissolution, promoting blood vessel dilation, stabilizing blood pressure, lipids, and blood sugar levels, and improving chronic inflammation and allergic conditions.

21.1 Exosome facial injection

Exosome facial rejuvenation injections help to increase collagen and elastin in the skin, significantly reducing fine lines, wrinkles, and age spots, while also effectively minimizing pores and improving skin texture.